Ethylbromazolam Powder CAS#105470-75-5

Ethylbromazolam exerts its effects by binding to the benzodiazepine site of the GABAA_AA​ receptor, enhancing GABA-mediated chloride influx

and neuronal hyperpolarization, which produces anxiolytic, sedative-hypnotic, anticonvulsant, and muscle relaxant effects. Its high potency at α1-, α2-, and α3-containing GABAA_AA​ receptors explains strong sedation and anxiolysis, while α5 activity may contribute to cognitive impairment. Potential applications, based on pharmacology, include treatment of anxiety, insomnia, and seizure disorders; however, due to its high potency, risk of dependence, and lack of clinical evaluation, it remains a research chemical rather than a therapeutic candidate.

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Ethylbromazolam is a benzodiazepine derivative^[1] which has been sold as a designer drug.^[2][3][4] It is structurally similar to bromazolam, only differing by the inclusion of an ethyl group instead of a methyl group on the triazole ring. It is in combination with its synthetic precursor desalkylgidazepam^[5] in samples expects to contain alprazolam only.

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Ethylbromazolam has an extremely limited history of human usage. Very little you can know about its pharmacological properties, metabolism, and potential toxicity.

It was first detected in the United Kingdom in February 2025,^[6] and has subsequently been detected in New Zealand in March 2025^[2] e Australia.^[3][4]

Comparison to Other Designer Benzodiazepines

• Ethylbromazolam structurally relates to bromazolam, which is increasingly discover in post-mortem toxicology 1
• Designer benzodiazepines vary in potency, with compounds like flubromazolam and clonazolam reported to be among the most potent 5
• Like etizolam, ethylbromazolam likely has anxiolytic, sedative, and potentially euphoric effects 4,5

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The emergence of designer benzodiazepines like ethylbromazolam represents a significant public health concern

particularly due to their unknown safety profiles and their presence in the illicit drug supply, often without users’ knowledge 1,2.

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As with the case of many classes of drugs, such as cathinones, the legal crack down on the benzodiazepine market has pushed producers to

explore and market new substances that are not prohibited or less controlled. This is where ethylbromazolam comes in. Molecularly, it is a small modification of bromazolam; bromazolam itself  already a designer benzodiazepine that grew in global popularity since its first detection in Sweden in 2016.

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Bromazolam in the News

There is more articles highlighting the incoming danger of bromazolam selling illicitly in the United States, sometimes falsely marketed as Xanax or Alprazolam. As of this blog post, here are three relevant news articles:

• August 29, 2023 – Indiana health officials warn about ‘emerging threat’ of drug Bromazolam
  • https://fox59.com/news/indiana-health-officials-warn-about-emerging-threat-of-drug-bromazolam/
• August 29, 2023 – ‘Fake Xanax:’ A worry to law enforcement, often mixed with deadly fentanyl
  • https://www.wane.com/top-stories/fake-xanax-a-worry-to-law-enforcement-often-mixed-with-deadly-fentanyl-and-its-in-fort-wayne/
• June 10, 2023 – Deadly drug just ‘a click away’, warns grieving Ontario family
  • https://www.cbc.ca/news/health/bromazolam-online-sales-warning-1.6869577

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References

1. Critical Review Report: Bromazolam, World Health Organization
2. European Drug Report 2023: Trends and Developments

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