Acetaminophen Powder

Buy Acetaminophen Powder Online EU,Acetaminophen, also known as N-acetyl-para-aminophenol (APAP) or paracetamol in many countries,

is a non-opioid analgesic and antipyretic agent utilized for treating pain and fever. Numerous diseases and conditions include pain as a significant component of their presentation.

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^[a] or acetaminophen,^[b] is a non-opioid analgesic e antipyretic agent used to treat fever and mild to moderate pain.^[14][15] It is a widely available over-the-counter drug sold generically or under various brand names, including Tylenol e Panadol.

Paracetamol relieves pain in both acute mild migraine and episodic tension headache.^[16][17] At a standard dose, paracetamol slightly reduces fever,^[14][18][19] though it is inferior to ibuprofen in that respect^[20] and the benefits of its use for fever are unclear, particularly in the context of fever of viral origins.^[21] The aspirin/paracetamol/caffeine combination also helps with both conditions when the pain is mild and is recommended as a first-line treatment for them.^[22] Paracetamol is effective for pain after wisdom tooth extraction, but it is less effective than ibuprofen.^[23]

The combination of paracetamol and ibuprofen provides greater analgesic efficacy than either drug alone.^[23][24] The pain relief paracetamol provides in osteoarthritis is small and clinically insignificant.^[15][25] Evidence supporting its use in low back pain, cancer pain, e neuropathic pain is insufficient.^{[15][26][27][28][29][30]} Paracetamol is the first-line treatment for pain and fever in pregnancy; no causal association with neurodevelopmental disorders has been established, while untreated pain and fever can harm the mother and fetus.^[31][32][33]

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In the short term, paracetamol is safe and effective when used as directed.^[34] Short term adverse effects are uncommon and similar to ibuprofen.^[35] Paracetamol is typically safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for long-term use.^[36] Paracetamol is also often used in patients who cannot tolerate NSAIDs like ibuprofen.^[37][38] Chronic consumption of paracetamol may result in a drop in hemoglobin level, indicating possible gastrointestinal bleeding,^[39] e abnormal liver function tests. The recommended maximum daily dose for an adult is three to four grams.^[26][40] Higher doses may lead to toxicity, including liver failure.^[41] Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand.^[42][43][44]

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Paracetamol was first made in 1878 by Harmon Northrop Morse or possibly in 1852 by Charles Frédéric Gerhardt.^[45][46][47] It is the most commonly used medication for pain and fever in both the United States and Europe.^[48] It is on the World Health Organization’s List of Essential Medicines.^[49] Paracetamol is available as a generic medication, with brand names including Tylenol e Panadol among others.^[50] In 2023, it was the 112th most commonly prescribed medication in the United States, with more than 5 million prescriptions.^[51][52]

Paracetamol is used for reducing fever.^[53] However, there has been a lack of research on its antipyretic properties, particularly in adults, and thus its benefits are unclear.^[14] As a result, it has been described as over-prescribed for this application.^[14] In addition, low-quality clinical data indicates that when used for the common cold, paracetamol may relieve a stuffed or runny nose, but not other cold symptoms such as sore throat, malaise, sneezing, ou cough.^[54]

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For people in critical care, paracetamol decreases body temperature by only 0.2–0.3 °C

more than control interventions and has no effect on their mortality.^[18] It did not change the outcome in febrile patients with stroke.^[55] The results are contradictory for paracetamol use in sepsis: higher mortality, lower mortality, and no change in mortality were all reported.^[18] Paracetamol offered no benefit in the treatment of dengue fever and was accompanied by a higher rate of liver enzyme elevation: a sign of potential liver damage.^[56] Overall, there is no support for a routine administration of antipyretic drugs, including paracetamol, to hospitalized patients with fever and infection.^[21]

The efficacy of paracetamol in children with fever is unclear.^[57] Paracetamol should not be used solely to reduce body temperature; however, it may be considered for children with fever who appear distressed.^[58] It does not prevent febrile seizures.^[58][59] It appears that 0.2 °C decrease of the body temperature in children after a standard dose of paracetamol is of questionable value, particularly in emergencies.^[14] Based on this, some physicians advocate using higher doses that may decrease the temperature by as much as 0.7 °C.^[19] Meta-analyses showed that paracetamol is less effective than ibuprofen in children (marginally less effective, according to another analysis^[60]), including children younger than 2 years old,^[61] with equivalent safety.^[20] Exacerbation of asthma occurs with similar frequency for both medications.^[62]

Paracetamol is used for the relief of mild to moderate pain such as headache,

muscle aches, minor arthritis pain, and toothache, as well as pain caused by cold, flu, sprains, and dysmenorrhea.^[63] It is recommended, in particular, for acute mild to moderate pain, since the evidence for the treatment of chronic pain is insufficient.^[15]

The benefits of paracetamol in musculoskeletal conditions, such as osteoarthritis and backache, are uncertain.^[15]

It appears to provide only small and not clinically important benefits in osteoarthritis.^[15][26] American College of Rheumatology e Arthritis Foundation guideline for the management of osteoarthritis notes that the effect size in clinical trials of paracetamol has been very small, which suggests that for most individuals it is ineffective.^[25] The guideline conditionally recommends paracetamol for short-term and episodic use to those who do not tolerate nonsteroidal anti-inflammatory drugs. For people taking it regularly, monitoring for liver toxicity is required.^[25] Essentially the same recommendation was issued by European League Against Rheumatism (EULAR) for hand osteoarthritis.^[64] Similarly, the ESCEO algorithm for the treatment of knee osteoarthritis recommends limiting the use of paracetamol to short-term rescue analgesia only.^[65]

Paracetamol is ineffective for acute low back pain.^[15][27] No randomized clinical trials evaluated its use for chronic or radicular back pain, and the evidence in favor of paracetamol is lacking.^[28][26][27]

Paracetamol is effective for acute migraine:^[16]

39% of people experience pain relief at one hour compared with 20% in the control group.^[66] The aspirin/paracetamol/caffeine combination also “has strong evidence of effectiveness and can be used as a first-line treatment for migraine”.^[22] Paracetamol on its own only slightly alleviates episodic tension headache in those who have them frequently.^[17] However, the aspirin/paracetamol/caffeine combination is superior to both paracetamol alone and placebo and offers meaningful relief of tension headache: two hours after administering the medication, 29% of those who took the combination were pain-free as compared with 21% on paracetamol and 18% on placebo.^[67] The German, Austrian, and Swiss headache societies and the German Society of Neurology recommend this combination as a “highlighted” one for self-medication of tension headache, with paracetamol/caffeine combination being a “remedy of first choice”, and paracetamol a “remedy of second choice”.^[68]

Pain after a dental surgery provides a reliable model for the action of analgesics on other kinds of acute pain.^[69] For the relief of such pain, paracetamol is inferior to ibuprofen.^[23] Full therapeutic doses of nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen, naproxen, ou diclofenac are clearly more efficacious than the paracetamol/codeine combination which is frequently prescribed for dental pain.^[70] The combinations of paracetamol and NSAIDs ibuprofen or diclofenac are promising, possibly offering better pain control than either paracetamol or the NSAID alone.^{[23][24][71][72]} Additionally, the paracetamol/ibuprofen combination may be superior to paracetamol/codeine and ibuprofen/codeine combinations.^[24]

A meta-analysis of general post-surgical pain, which included dental and other surgery,

showed the paracetamol/codeine combination to be more effective than paracetamol alone:

it provided significant pain relief to as much as 53% of the participants, while the placebo helped only 7%.^[73]

Paracetamol fails to relieve procedural pain in newborn babies.^[74][75] For perineal pain postpartum paracetamol appears to be less effective than nonsteroidal anti-inflammatory drugs (NSAIDs).^[76]

The studies to support or refute the use of paracetamol for cancer pain and neuropathic pain are lacking.^[29][30] There is limited evidence in favor of the use of the intravenous form of paracetamol for acute pain control in the emergency department.^[77] The combination of paracetamol with caffeine is superior to paracetamol alone for the treatment of acute pain.^[78]