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1P-LSD Blotters For Sale Online. 1P-LSD (1-propanoyl-lysergic acid diethylamide) is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It originated in 2015 when it appeared a designer drug sold online.^{[1][2][3][4][5][6]} It modifies the LSD molecule by adding a propionyl group to the nitrogen molecule of LSD’s indole group

Pharmacology

Like ALD-52, 1P-LSD is believed to act as prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum,^[9] administered intravenously to rats,^[10] or administered either orally or intravenously to human subjects,^[11] high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in vivo following ingestion. Indeed, following intravenous administration in humans 1P-LSD is detectable in serum for no longer than 4 hours, after which it is completely converted to LSD.^[11] These findings are supported by the similar duration and behavioral effects of 1P-LSD and LSD in both animal and human experiments.^[9][11]

Effects

The subjective effects of 1P-LSD are not well defined in the scientific literature, although they are generally thought to be comparable to that of LSD.^[12] In a 2020 study, the qualitative effects of 1P-LSD and LSD were similar when measured using visual analog scales.

Legal status

As of 2015, 1P-LSD is unscheduled in the United States and Canada, but may be considered illegal if sold or used for human consumption as a structural analog of LSD under the Federal Analogue Act in the US.^[9] 1P-LSD is a prohibited or controlled substance in Australia, France,^[13] Finland,^[14] Denmark,^[15] Germany,^[16] Estonia,^[17] Japan,^[18] Latvia,^[19] Norway,^[20] Romania,^[21] Sweden,^[22] Switzerland,^[23] United Kingdom,^[24] Italy,^{[citation needed]} Singapore,^[25] the Czech Republic,^[26] and Croatia.^[27] 1P-LSD has been illegal in Russia since 2017 as an LSD derivative.^[28]