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Kúpte si Oxykodón online 10 mg, 30 mg online
Oxycodone is an opioid medicine available for the management of moderate to severe pain. It is an oral medication in both immediate-release and extended-release formulations. Oxycodone’s onset of action typically begins within 15 minutes, and effects wear off in about six hours for immediate-release forms. People can also buy oxycodone online in combination with acetaminophen or aspirin.
Oxykodón je účinnejší ako morfín, keďže štúdie ukazujú, že 5 mg oxykodónu má približne 1,5-násobok účinnosti 5 mg morfínu.
Nemci prvýkrát vyrobili oxykodón z tebaínu v roku 1916. V Spojených štátoch je liek dostupný aj ako generická verzia s veľkoobchodnou cenou nižšou ako $0,30 za tabletku.
Oxykodón je jedným z najčastejšie predpisovaných opioidných analgetík v Spojených štátoch s viac ako 10 miliónmi receptov ročne.
Použitie oxykodónu
You can buy oxycodone online for managing your pain conditions ranging from moderate to severe acute or chronic pain. Doctors prescribe oxycodone only when other treatment options such as combination opioids or non-opioid analgesics are not sufficient for a patient to provide required pain relief. The medication may also improve the quality of life in certain conditions.
Oxycodone also comes as controlled released tablets that have analgesic effects ranging for about 12 hours. An independent study conducted in July 1996 found that oxycodone’s controlled-release form has a variable action duration ranging from 10 to 12 hours.
Prehľad vytlačený v roku 2006 hovorí, že kontrolované uvoľňovanie oxykodónu je porovnateľné s jeho formami s okamžitým uvoľňovaním, hydromorfónom a morfínom pri liečbe bolesti pri rakovine, s menším počtom vedľajších účinkov ako iné. Dospel k záveru, že oxykodón s riadeným uvoľňovaním je prvolíniovou liečbou a platnou alternatívou morfínu pri rakovinovej bolesti.
FDA Spojených štátov schvaľuje oxykodón formy s predĺženým uvoľňovaním pre deti vo veku 11 rokov a viac na úľavu od bolesti po traume, bolesti pri rakovine alebo bolesti v dôsledku chirurgického zákroku len pre deti, ktoré už boli liečené opioidnými analgetikami a ktoré znášajú aspoň 20 mg oxykodónu denne.
Mechanizmus akcie
Oxykodón je umelý alebo polosyntetický opioid, ktorý je selektívnym úplným agonistom MOR (mu-opioidný receptor), primárneho biologického cieľa endogénneho opioidného neuropeptidu beta-endorfínu. Liek má nízku afinitu ku KOR (k-opioidný receptor) a DOR (delta opioidný receptor), kde je agonistom. Po naviazaní na MOR oxykodón uvoľňuje G proteínový komplex, ktorý inhibuje uvoľňovanie bunkových neurotransmiterov znížením produkcie cAMP, otvorením kanálov draslíka a uzavretím kanálov vápnika.
Vedci sa domnievajú, že oxykodón vytvára svoje analgetické účinky aktiváciou MOR v strednom mozgu PAG (periaqueduktálna šedá) a RVM (rostrálna ventromediálna dreň). Naopak, poskytujú závislosť aktiváciou MOR v MRV (mezolimbická dráha odmeňovania), vrátane ventrálneho pallidum, nucleus accumbens a ventrálnej tegmentálnej oblasti.
Nepriaznivé účinky
Oxycodone produces several side effects along with its needed healing impact. People should buy oxycodone online only on a doctor’s prescription. Severe side effects of the medication include reduced sensitivity to pain, anxiolysis, euphoria, feelings of relaxation, and respiratory depression.
Niektoré bežné nežiaduce účinky oxykodónu zahŕňajú:
- Nevoľnosť (23%)
- Zápcha (23%)
- Somnolencia (23%)
- Svrbenie (13%)
- Závraty (13%)
- Vracanie (12%)
- Sucho v ústach (6%)
- Potenie (5%)
Menej časté vedľajšie účinky oxykodónu, ktoré zaznamenalo menej ako 5 pacientov s %, zahŕňajú nervozitu, stratu chuti do jedla, hnačku, bolesť brucha, dyspnoe, zadržiavanie moču a škytavku.
Väčšina nežiaducich účinkov sa postupom času zmenšuje a postupne vymizne v priebehu niekoľkých dní alebo do týždňa. Je však pravdepodobnejšie, že zápcha bude pokračovať počas užívania.
Interakcie
The medication interacts with many drugs to produce unwanted effects. It is advisable to buy oxycodone online and read the label instructions to know about all its potential drug interactions.
Enzymes such as CYP3A4 and CYP2D6 metabolize oxycodone. So, the inhibitors and inducers of these enzymes can alter the clearance of oxycodone by increasing and decreasing the medication’s half-life, respectively. Genetic variations in these enzymes also influence the removal of oxycodone, which relates to the wide inter-person variability in its potency and half-life.
Lopinavir/ritonavir or ritonavir significantly increase oxycodone’s plasma concentrations in healthy humans due to inhibition of CYP2D6 and CYP3A4.
Rifampicin reduces oxycodone’s plasma concentration due to its active CYP3A4 inducing property. In a chronic pain patient, fosphenytoin, an inducer of CYP2A4, dramatically reduces the analgesic effects of oxycodone.
V prípade liekových interakcií je potrebné, aby lekár upravil dávkovanie alebo lieky.
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